Examining the Relative Influence of Familial, Genetic and Environmental Covariate Information in Flexible Risk Models With Application to Ophthalmology Data
نویسندگان
چکیده
Héctor Corrada Bravo1 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Grace Wahba1 Department of Statistics, Department of Computer Science and Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI Kristine E. Lee2, Barbara E.K. Klein2, Ronald Klein2 Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WI Sudha K. Iyengar3 Department of Epidemiology and Biostatistics, Department of Genetics and Department of Ophthalmology, Case Western Reserve University, Cleveland, OH
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Examining the relative influence of familial, genetic, and environmental covariate information in flexible risk models.
We present a method for examining the relative influence of familial, genetic, and environmental covariate information in flexible nonparametric risk models. Our goal is investigating the relative importance of these three sources of information as they are associated with a particular outcome. To that end, we developed a method for incorporating arbitrary pedigree information in a smoothing sp...
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